• Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology 

      Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland; Michelsen, Annika Elisabet; Ranheim, Trine; Nezvalova-Henriksen, Katerina; Dyrhol-Riise, Anne Ma; Holme, Pål Andre; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Ahlen, Maria Therese; Aukrust, Pål; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-28)
      Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are scarce. We assessed the presence of anti-PF4/polyanion antibodies in prospectively collected serum from an unselected cohort ...
    • SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people 

      Garabet, Lamya Samir Noori; Eriksson, Anna Maria; Tjønnfjord, Eirik; Cui, Xueyan; Olsen, Magnus Kringstad; Jacobsen, Hege; Jørgensen, Camilla Tøvik; Mathisen, Åse-Berit; Mowinckel, Marie-Christine; Ahlen, Maria Therese; Sørvoll, Ingvild Hausberg; Horvei, Kjersti Daae; Ernstsen, Siw Leiknes; Lægreid, Ingvild Jenssen; Stavik, Benedicte; Holst, Rene; Sandset, Per Morten; Ghanima, Waleed (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      Background: SARS-CoV-2 adenoviral vector DNA vaccines have been linked to the rare but serious thrombotic postvaccine complication vaccine-induced immune thrombotic thrombocytopenia. This has raised concerns regarding the possibility of increased thrombotic risk after any SARS-CoV-2 vaccines. <p><p>Objectives: To investigate whether SARS-CoV-2 vaccines cause coagulation activation leading to a ...
    • Thrombosis and thrombocytopenia after HPV vaccination 

      Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes; Azrakhsh, Nessar Ahmad; Kittang, Astrid Marta Olsnes; Lindås, Roald; Gjertsen, Bjørn Tore; Vetti, Nils; Mørtberg, Trude Victoria; Sørvoll, Ingvild Hausberg; Holme, Pål Andre; Ahlen, Maria Therese; Reikvam, Håkon (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-24)
      Background - Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.<p> <p>Objective - We report findings in a 25-year-old woman who presented with thrombocytopenia, venous thrombosis, elevated D-dimer levels, and high levels of platelet-activating antibodies to platelet ...
    • Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study 

      Schultz, Nina Haagenrud; Søraas, Arne Vasli; Sørvoll, Ingvild Hausberg; Akkøk, Cigdem Ahaein; Vetlesen, Annette; Bhamra, Jagjit Singh; Ahlen, Maria Therese; Holme, Pål Andre; Aamodt, Anne Hege; Skagen, Karolina Ryeng; Skattør, Thor Håkon; Skjelland, Mona; Wiedmann, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Objectives Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in cerebral veins, thrombocytopenia and anti-PF4/polyanion antibodies. Prolonged headaches and cutaneous hemorrhages, frequently observed after the ChAdOx1 ...
    • Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series 

      Wiedmann, Markus; Skattør, Thor Håkon; Stray-Pedersen, Arne; Romundstad, Luis Georg; Antal, Ellen-Ann; Marthinsen, Pål Bache; Sørvoll, Ingvild Hausberg; Ernstsen, Siw Leiknes; Lund, Christian G.; Holme, Pål Andre; Johansen, Tonje Okkenhaug; Brunborg, Cathrine; Aamodt, Anne Hege; Schultz, Nina Haagenrud; Skagen, Karolina Ryeng; Skjelland, Mona Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
      During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and ...